2016 Fiscal Year Final Research Report
Transcriptional regulation in the developing brain that influences on the neural plasticity after maturation and its disruption mechanisms by environmental chemicals
| Project/Area Number |
26860852
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Tanida Takashi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30589453)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エストロゲン関連受容体(ERR) / 生細胞イメージング / FRAP / FRET / 神経突起伸長 / PGC-1α / エストロゲン受容体(ER)α |
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| Outline of Final Research Achievements |
Estrogen receptor (ER)α plays pivotal roles in normal brain development, postsynaptic plasticity, and the pathology of neuropsychiatric disorders. In this study, the roles of estrogen-related receptor (ERR), which has strong homology with ERα, in the function of ERα was analyzed. The distribution of ERR in the rat brain was also shown. Furthermore, the investigator identified the novel variant form of PGC-1α, the transcriptional coactivator of ERR from the rat hypothalamus. The function of this variant form on the ERR transactivity and its effect on the neurite outgrowth were demonstrated.
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| Free Research Field |
神経解剖学、内分泌・代謝学、胎児・新生児医学
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