Investigations for MUC5AC ecpresion in exramammary Paget disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860862
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Hokkaido University
• Principal Investigator: Hata Hiroo 北海道大学, 医学研究科, 助教 (90399915)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 皮膚腫瘍

Outline of Final Research Achievements

Patients with in situ extramammary Paget's disease (EMPD) tend to have a good prognosis, although dermal invasion and metastasis are associated with significantly increased morbidity and mortality. No molecular markers that reflect invasiveness or progression have been established. We performed an initial microarray screening for in situ, invasive or metastatic lymph node lesions of EMPD, showing MUC-family overexpression. We analysed 44 specimens from 38 primary EMPD cases by immunohistochemical staining. We found that expressions of MUC5AC directly correlate with invasion and prognosis. MUC5AC expression was detected in 19 of 44 (43.2%) specimens. Invasive lesions and metastatic lymph nodes tended to express MUC5AC significantly higher than in situ lesions. Together, the degree of MUC5AC expression may correlate with the invasiveness and progression of EMPD, and may be a useful marker for identifying high-risk EMPD cases.

Free Research Field

皮膚腫瘍学