Longitudinal Study for Brain Functions of Remission and Recovery in Mood disorders and Schizophrenia

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860914
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: Takizawa Ryu 東京大学, 医学部附属病院, 助教 (30420243)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 統合失調症 / 気分障害 / 寛解 / 回復 / 脳機能 / 縦断的研究 / 双生児法 / ストレス

Outline of Final Research Achievements

The main purpose of this research is to elucidate the underlying brain functions not only for ‘(symptomatic) Remission’ but also for ‘Recovery’ which includes social functioning, subjective well-being and quality of life (QOL). We showed the potential applicability of near-infrared spectroscopy (NIRS) for differential diagnosis of the patients with depressive symptoms. However, the applicability of NIRS to the assessment of symptom and prognostic prediction remains to be elucidated.
Prospectively we have measured the baseline, 1.5-year and 3-year follow-ups in healthy controls and patients. Our results showed that there is a possibility that prefrontal and temporal NIRS signals have state-dependent and trait-dependent characteristics (for symptoms, functioning and QOL) on the basis of differential brain regions. The current research has shown the potential applicability to the assessment of symptom and the establishment of prognostic prediction.

Free Research Field

精神医学・臨床心理学・健康科学