2015 Fiscal Year Final Research Report
The therapeutic potential of BDNF and epigenetic changes in the animal model of PTSD.
| Project/Area Number |
26860928
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 心的外傷後ストレス障害 / 脳由来神経栄養因子 |
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| Outline of Final Research Achievements |
In this study, we examined the effect of Brain-derived neurotrophic factor (BDNF) on the impaired fear extinction of the animal model of PTSD. The rat model of PTSD exhibited the impaired fear extinction and the decrease of the expression of BDNF protein just before extinction training in both prefrontal cortex (PFC) and hippocampus. In addition, the micro-infusion of BDNF into infralimbic PFC and into ventral hippocampus reduced the freezing of PTSD model rat 24hr and 48hr after fear conditioning.
Our results indicates the potential of BDNF as a new therapeutic agent for the treatment of PTSD.
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| Free Research Field |
分子精神医学
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