2017 Fiscal Year Final Research Report
Investigation of the mechanism for and psychiatric symptoms due to elevation of inflammatory cytokines in mood disorders.
| Project/Area Number |
26860946
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | うつ病 / 気分障害 / サイトカイン / 酸化ストレス / 動物モデル |
|---|
| Outline of Final Research Achievements |
The study aimed to clarify the mechanism for the elevation of inflammatory cytokines, and the psychiatric symptoms produced by it, in major depressive disorder (MDD) through clinical investigation and the use of an animal model.
However, in this study there were no significant differences in inflammatory cytokines between MDD patients and normal controls (NC). On the other hand, the oxidative stress marker was more elevated in MDD patients than NC.
Transgenic (Tg) mice with regulated expression of SITH-1 (the latent protein of human herpesvirus 6) were prepared. Although the Tg mice showed depressive-like behavior compared to wild-type mice, there was no significant association between SITH-1 and the inflammatory cytokine.
|
| Free Research Field |
精神神経科学
|
