Development of percutaneous inserting absorbable spacer for radiotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860970
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Jingu Keiichi 東北大学, 医学系研究科, 教授 (00451592)
• Research Collaborator: TAKEDA Kazuya
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 放射線治療 / スペーサー / 吸収型

Outline of Final Research Achievements

Some types of spacer for injection are commercially available and surgical implantation of spacer for radiotherapy has been reported. However, surgical implantation has a probability of infection and it is difficult to insert it in appropriate site. Therefore, we try to find materials which can be injected under CT guidance safely as spacer. we focused gelatin polymer gel (RM-100HS, Kanto Kagaku), which had been used for vascular embolization.　Five mice received injection of 0.3 cc of that gelatin polymer gel into the back subcutaneous tissue. CT scan were obtained at day 0, 1, 3, 7, 14, 21 and 35. In first 24 hours, the volume increased 112±31%. The volume of gel was stable between day 1 and day 21, with volume change between -11% and +15%. At day 35 after injection, major variation of the volume was observed. During the observation period, no major toxic effect was observed macroscopically and histologically.

Free Research Field

放射線治療