2016 Fiscal Year Final Research Report
Elucidation of the mechanism of radiation damage enhancement using collagen disease model mouse
| Project/Area Number |
26860975
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Research Collaborator |
Fukumoto Manabu
Mori Shiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 放射線障害 / 放射線皮膚炎 / 膠原病モデルマウス |
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| Outline of Final Research Achievements |
We studied whether radiation damage was increased in collagen disease model mice. We irradiated RA model mice, SLE model mice and C3H/Hej mice as normal control. We performed only on the left lung for 20 Gy and 30 Gy. Dermatitis was evaluated by the score. Both the collagen disease model mice groups had high scores and the dermatitis prolonged in the 30 Gy irradiation groups. In the histological evaluation at 7, 14, 28, 56, and 84 days after irradiation, epidermal hypertrophy began to be conspicuous on the 28th day in each groups. Although Epidermal hypertrophy in the control group was improved on the 56th day , it was not improved in both disease model mouse groups, and this response was also observed on day 84. In pulmonary histological evaluation, the interstitial thickening and the infiltration of inflammatory cells were gradually observed in each group compared with non-irradiated lungs,but it may reflected a vasculitis in disease model mice.
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| Free Research Field |
放射線腫瘍学
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