Development of the sigma-2 receptor imaging agent for the purpose of early detection and the proliferation potency diagnosis of the solid tumor

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860987
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Kozaka Takashi 金沢大学, 学際科学実験センター, 助教 (50579836)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: σ-2受容体 / vesamicol / 分子イメージング

Outline of Final Research Achievements

Expression of sigma-2 receptor is seen in many kinds of solid tumor cell, such as breast cancer and the pancreatic cancer, and sigma-2 receptor of up to 10 times overexpressed in the proliferation period. In other words, sigma-2 receptor was important biomarker of the solid tumor cell for the proliferation period, and sigma-2 receptor imaging is estimated to possess the possibility for early detection and the increase ability diagnosis of cancer. [125I]PIDV, which I developed in this study, showed superior sigma-2 receptor accumulation in in vitro and in vivo and [123I]PIDV worked successfully in sigma-2 receptor imaging with tumor-bearing mouse (human breast adenocarcinoma cell line MCF-7) by the SPECT.

Free Research Field

分子イメージング