2016 Fiscal Year Final Research Report
Relationship between inhibition of glutamate-glutamine cycle and 14C-Acetate uptake in rat brain
| Project/Area Number |
26860992
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 酢酸 / グリア細胞 / グルタミン酸ーグルタミンサイクル |
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| Outline of Final Research Achievements |
The brain uptake of 14C-acetate in the dysfunction of glutamate-glutamine (Glu-Gln) cycle between neuron and glia was measured. In the neuronal or glial cells-lesioned rat model, the uptake of 14C-acetate was decreased in the lesioned area. Furthermore, the 14C-acetate uptake was also reduced in the dihydrokainate (an inhibitor of glutamate transporter-1)-infused rat brain. These results suggest that the 14C-acetate uptake into glial cells might be affected by the process of uptake of glutamate into glial cells.
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| Free Research Field |
医歯薬学
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