Functional image-guided dosimetric evaluation for the radiotherapy treatment planning of liver tumors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861004
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: TOYA Ryo 熊本大学, 医学部附属病院, 講師 (60452893)
• Research Collaborator: NAMIMOTO Tomohiro ; SHIRAISHI Shinya ; FUKUGAWA Yoshiyuki
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 放射線治療 / 定位放射線治療 / 分子イメージング / 機能画像 / 画像誘導放射線治療 / 低侵襲治療 / 放射線肝障害 / 線量体積ヒストグラム

Outline of Final Research Achievements

We introduced functional images into dosimetric evaluation for the radiotherapy treatment planning of liver tumors. We evaluated hepatocellular carcinoma (HCC) patients treated with stereotactic radiotherapy of 30-40 Gy in five fractions. We calculated dose-function histogram parameters based on 99mTc-GSA SPECT/CT images and found that the history of prior treatment significantly influenced on the parametric discrepancy between dose-function and dose-volume histogram. We also evaluated HCC patients treated with 3D-conformal radiotherapy of 45 Gy in 15 fractions. We investigated the relationship between radiotherapy dose and focally decreased enhancement of Gd-EOB-DTPA-enhanced MRI. The threshold dose was approx. 35 Gy. Our results may facilitate the precise prediction for the radiation-induced liver disease.

Free Research Field

放射線腫瘍医学