Development of new treatment with MRI-detectable polymeric micelles incorporating platinum anticancer drugs against hepatocellular carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Kaida Sachiko 滋賀医科大学, 医学部, 特任助教 (70710234)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 高分子ミセル / ドラッグデリバリーシステム / 抗癌剤 / MRI造影剤 / 肝細胞癌

Outline of Final Research Achievements

We used polymeric micelles containing the T1-weighted magnetic resonance imaging contrast agent gadolinium-diethylenetriaminpentaacetic acid (Gd-DTPA) and the parent complex of the anticancer drug oxaliplatin [(1,2-diaminocyclohexane)platinum(II) (DACHPt)] for simultaneous imaging and therapy in an orthotopic rat model of HCC. The Gd-DTPA/DACHPt-loaded micelles were injected into the hepatic artery, and magnetic resonance imaging performance and antitumor activity against HCC, as well as adverse drug reactions were assessed. After a single administration, the micelles achieved strong and specific tumor contrast enhancement, induced high levels of tumor apoptosis, and significantly suppressed tumor size and growth. Moreover, the micelles did not induce severe adverse reactions and significantly improved survival outcomes in comparison to oxaliplatin or saline controls.

Free Research Field

消化器外科