2015 Fiscal Year Final Research Report
New treatment strategy via autophagy for pancreatic adenocarcinoma.
| Project/Area Number |
26861089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Research Collaborator |
SAKATA Kazuya 熊本大学, 医学部附属病院, 非常勤診療医師
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | オートファジー / 膵癌 / ゲムシタビン / フルオロウラシル |
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| Outline of Final Research Achievements |
Autophagy is a regulated process of degradation and recycling of cellular constituents. The role of autophagy in pancreatic cancer is still not clear. The aim of this study was to investigate the role of autophagy in pancreatic cancer, and to provide insights into new strategies for treatment.
During study period, about 50 patients with pancreatic cancer underwent pancreatic resection. Autophagy was significantly induced in pancreatic ductal adenocarcinoma compared to healthy pancreatic tissue in these patients. The association of autophagy status with long-term survival has been analyzed.
In pancreatic cancer cell lines, autophagy contributes to pancreatic cancer cell growth, and has a cytoprotective effect against anti-cancer drug. These data were published in Euro J Cancer.
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| Free Research Field |
消化器外科学
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