2015 Fiscal Year Final Research Report
A novel split liver protocol using the subnormothermic oxygenated circuit system in a marginal donor procedure
| Project/Area Number |
26861101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Okada Noriki 自治医科大学, 医学部, 臨床助教 (40611786)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 常温酸素化灌流 / 肝移植 / 臓器保存 / 分割肝移植 |
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| Outline of Final Research Achievements |
This study was performed with the goal of devising a new split liver protocol.
First, as the research of appropriate condition of subnormothermic oxygenated prefusion, the necessity of the oxygen carrier was examined. It is suggested that the oxygen carrier makes higher graft preservative effect.
Second, a novel split liver protocol using the subnormotheric oxygenated circuit system in a porcine model was performed.This study revealed that the subnormothermic oxygenated circuit system is more efective than cold storage which has been used in clinical situation in split liver protocol. This protocol may help to overcome the lack of brain-death donor liver graft.
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| Free Research Field |
肝移植
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