New organ preservation method using modified Ex vovo lung perfusion

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861121
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kobe University
• Principal Investigator: Tanaka Yugo 神戸大学, 医学(系)研究科(研究院), 准教授 (20403256)
• Research Collaborator: SHIGEMURA NORIHISA ピッツバーグ大学, 胸部移植外科, 准教授 ; TANE SHINYA ピッツバーグ大学, 胸部移植外科, 研究員
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 肺移植 / 臓器保存 / Ex vivo lung perfusion

Outline of Final Research Achievements

We evaluated the feasibility of dual-perfusion techniques with the bronchial artery circulation and pulmonary artery circulation synchronously perfused using ex vivo lung perfusion (EVLP) and evaluate the effects of dual perfusion on posttransplant lung graft function. Our results demonstrated that dual-EVLP yields better posttransplant graft function through increased microvasculature and better perfusion of the lung grafts after transplantation.

Free Research Field

呼吸器外科