Innovation of cancer therapies based on anti-aging klotho gene

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Tokyo Medical University
• Principal Investigator: KUDO YUJIN 東京医科大学, 医学部, 助教 (80623800)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: klotho / アンチエイジング / 肺癌 / 予後

Outline of Final Research Achievements

We reported that the klotho gene, which was an anti-aging gene, affected the prognosis of lung cancer patients. We also found that a high expression of the klotho protein could markedly increase the apoptotic response of cancer cells to taxanes, anti-cancer agents. The expression of klotho protein was not associated with those of class III β-tubulin and P glycoprotein. Klotho expression was a significant prognostic factor in patients with pN2 lung cancer, and those without klotho expression had worse survival than those with klotho expression. The potential for high-grade malignancy was also investigated in patients who underwent surgical resection for lung cancer or those with postoperative recurrence.

Free Research Field

呼吸器外科