2015 Fiscal Year Final Research Report
New approach for glioblastoma with immuno-chemotherapy using severe immunodeficiency mouse
Project/Area Number |
26861159
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
|
Research Institution | Nara Medical University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 脳腫瘍 / 膠芽腫 / NK細胞 / γδT細胞 / temozolomide / 免疫療法 / bisphosphonate |
Outline of Final Research Achievements |
Our aim to investigate is to establish the new approach for glioblastoma. We demonstrated that combination therapy with gamma delta T cell and bisphosphonate had a significant strong anti-tumor effect for transplanted glioblastoma cells into NOG mouse. In second experiment, we demonstrated that NK cells had a strong anti-tumor effect for temozolomide-resistant glioblastoma cells in vitro. In conclusion, gamma delta T cell and NK cells are promising cell source for glioblastoma.
|
Free Research Field |
脳腫瘍
|