2015 Fiscal Year Final Research Report
Investigation of the effect of glycative stress on bone repair and development of new method of osteogenesis in diabetic patients
| Project/Area Number |
26861176
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | メチルグリオキサール / 糖化ストレス / 骨修復能 |
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| Outline of Final Research Achievements |
In diabetic mice, the amount of AGEs in the serum and the femur significantly increased. In particular, methylglyoxal (MG)-derived AGEs were often found in the femur. Furthermore, MG plays a role in inhibiting the differentiation and proliferation of bone cells. In conclusions, MG was increased in diabetes mouse and acted directly to inhibit differentiation and proliferation of osteoblast resulting in delayed bone formation in diabetes. Therefore, activation of MG detoxification enzyme and administration of an MG scavenger is expected to improve bone repair.
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| Free Research Field |
整形外科
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