Development of new strategy for rheumatoid arthritis and osteoarthritis applying human mesenchymal stem cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 26861214
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Showa University
• Principal Investigator: Sato Atsushi 昭和大学, 医学部, 講師 (10445596)
• Research Collaborator: OHTAKI HIROKAZU
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 変形性膝関節症 / 骨髄間葉系幹細胞 / 関節リウマチ

Outline of Final Research Achievements

Cell therapy for rheumatoid arthritis and osteoarthritis is becoming important recently. One of the treatment method is human mesenchymal stem cells (hMSCs). Inflammatory cytokines such as IL-1, TNF alpha, IL-10 and TGF beta, decreased and an anti-inflammatory cytokine IL-4 increased after spinal cord injury in mice transplanted hMSCs. We revealed that hMSCs regulated anti-inflammatory effect through pituitary adenylate cyclase activating peptide (PACAP). We also reported that chemokine CCL5 and its receptor, CCR1 and CCR5, increased through 14th day after injury by RT-PCR using mRNA of injured tissues. It suggested that CCL5 was involved in chronic inflammatory phase and It was important for the treatment period.

Free Research Field

整形外科