Investigation of hypoxia resistance in renal cell carcinoma based on functional RNA network analyses

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861276
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kagoshima University
• Principal Investigator: Chiyomaru Takeshi 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (60593796)
• Research Collaborator: NAKAGAWA MASAYUKI 鹿児島大学, 医歯学総合研究科, 教授 (90164144) ; ENOKIDA HIDEKI 鹿児島大学, 医歯学総合研究科, 准教授 (80347103) ; SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 腎細胞癌 / マイクロRNA / 低酸素

Outline of Final Research Achievements

We found that MYC oncogene was directory regulated by miR-135a. miR-1291 also regulated glucose transporter 1 (SLC2A1/GLUT1). miR-143/145 is a tumor suppressive cluster microRNA, and they had a common target hexokinase 2 gene. Down regulation of miR-135a, miR-1291, miR-143, and miR-145 might activate glycolytic pathway and maintain ATP synthesis under hypoxia circumstances in renal cell carcinoma.

Free Research Field

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