The role of GDNF-RET cascade for the development of benign prostate hyperplasia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861285
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: SHIBATA Yasuhiro 名古屋市立大学, 大学院医学研究科, 助教 (10534745)
• Research Collaborator: SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 研究員 (50225869) ; UGAWA Shinya 名古屋市立大学, 大学院医学研究科, 教授 (20326135)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 前立腺肥大症 / GDNF

Outline of Final Research Achievements

Although benign prostate hyperplasia (BPH) is common disease, the cause of BPH is still unclear.　To investigate the mechanism of BPH development, we use the novel BPH model which was made by implanting the urogenital sinus of neonatal rats to sub-capsule of the prostate of adult male rats. 　Using this model we discovered the grail-cell derived neurotrophic factor (GDNF) expresses in interstitial cell. And we demonstrate that GDNF increase the growth rate of human prostate interstitial cell-line, and RET signal cascade was related with prostate volume positively in human BPH tissue.

Free Research Field

泌尿器科学