2015 Fiscal Year Final Research Report
CXCL1 signaling is a crucial mediator between cancer cells and tumor-associated macrophages/cancer-associated fibroblasts for tumor invasion and progression in microenvironment of human bladder cancer
| Project/Area Number |
26861290
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
Miyake Makito 奈良県立医科大学, 医学部, 助教 (80601400)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | Bladder cancer / tumor micro environment / macrophage / fibroblast |
|---|
| Outline of Final Research Achievements |
Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are reported to have association with poor prognosis, depending on their tumor-supportive roles. Current knowledge of TAMs and CAFs in tumor microenvironment of urothelial cancer the bladder (UCB) is limited. Here, we focused on the biological behavior of CXCL1 signaling for induction of TAMs/CAFs which support the tumor growth and angiogenesis. In conclusion, CXCL1 signaling in tumor microenvironment may be highly responsible for repeated intravecial recurrence and disease progression through enhanced invasion ability. Breaking the CXCL1 signaling is an attractive therapeutic approach for human UCB in which this chemokine is aberrantly regulated.
|
| Free Research Field |
Bladder cancer
|
