To uncover the pathogenesis of preeclampsia.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: National Center for Child Health and Development (2016); Yamagata University (2014-2015)
• Principal Investigator: Amita Mitsuyoshi 国立研究開発法人国立成育医療研究センター, 周産期・母性診療センター, 医員 (30420061)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 妊娠高血圧症候群 / iPS細胞 / trophoblast

Outline of Final Research Achievements

One of the cause of preeclampsia is thought to be poor placentation developed in early pregnancy. Understanding the pathogenesis of the diseases has been hampered by inaccessibility to the early stages of human placental tissue. In this study, we examined to derive iPSC from human umbilical cord and differentiate into trophoblast. Longer term goal is to generate iPSC from umbilical cords of preeclampsia patients to generate abnormal placental models to uncover the mechanisms of the disease.

Free Research Field

産婦人科学