2015 Fiscal Year Final Research Report
Establishment of molecular pathological
Project/Area Number |
26861312
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
|
Research Institution | Chiba University |
Principal Investigator |
KAKU Hiroshi 千葉大学, 医学部附属病院, 医員 (40456059)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 絨毛性疾患 / 胚細胞性腫瘍 |
Outline of Final Research Achievements |
Precise diagnosis of hydatidiform mole is important because some extent of molar patients would be developing into gestational trophoblastic neoplasia. The aim of this study was the establishment of molecular pathological diagnosis with p57KIP2 immunohistochemistry and Chromogenic in situ Hybridization (CISH). The immune staining of p57KIP2 determined androgenetic hydatidiform moles. Otherwise, CISH discriminated the triploidy of partial hydatidiform moles from biparental diploid abortion. Seventy-five percent of cases demonstrated the appropriated CISH signals, although twenty-five percent of cases did not indicate the signals. To get the stable signal, the methods of the fixation of the villous sample could be critical. Further investigation would be necessary.
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Free Research Field |
婦人科学
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