The role of seminal fuid in paternal antigen specific feto-maternal tolerance

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861316
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: Shima Tomoko 富山大学, 医学薬学研究部(医学), 助教 (00377285)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 精漿 / 父親抗原特異的制御性T細胞 / 免疫寛容誘導性樹状細胞 / 母児免疫寛容

Outline of Final Research Achievements

Fetus is a semi-allograft to maternal immune system. We have shown that paternal antigen specific regulatory T cells have an active role for feto-maternal tolerance. And, it is known that antigen specific regulatory T cells are induced after antigen presentation by tolerogenic dendritic cells (DC).
We analyzed the role of seminal fuid in paternal antigen specific feto-maternal tolerance with focused on paternal antigen specific Treg and tolerogenic DC.
Seminal fluid priming is important for the induction of tolerogenic DC and patarnal antigen specific Treg. The crosstalk of DC and Treg is important for success of pregnancy.

Free Research Field

産科婦人科