Comprehensive metabolomics among tumor-related genes

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861324
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: Yamaguchi Ken 京都大学, 医学(系)研究科(研究院), 助教 (20378772)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 卵巣癌 / エピジェネティック / 代謝

Outline of Final Research Achievements

Ovarian clear cell carcinoma (CCC) is a histologic subtype of epithelial ovarian cancer (EOC) with unique characteristics including chemoresistance and carcinogenic origins from endometriotic cysts. We identified that HNF1B which is expressing highly in CCC contributes to proliferation in the stress environment. HNF1B also affects the chemoresistance through Warburg effect and glutathione synthesis. ARID1A is a subunit of SWI/SNF complex. Although ARID1A expression was not related to poor prognosis, the SWI/SNF-negative group exhibited significantly shorter progression-free and overall survival (p<0.05). Multivariate analysis suggested that SWI/SNF complex expression status was an independent prognostic factor.

Free Research Field

卵巣癌