2016 Fiscal Year Final Research Report
Pivotal roles of CX3CL1-CX3CR1 systems in ovarian cancer progression
| Project/Area Number |
26861338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Horiuchi Yuko 和歌山県立医科大学, 医学部, 博士研究員 (60596972)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 卵巣癌 / 微小環境 / ケモカイン・サイトカイン / 腹膜播種 |
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| Outline of Final Research Achievements |
Despite the development of cytoreductive surgery and chemotherapy, epithelial ovarian cancer has the highest case-fatality rate among gynecologic cancers. In the biology of tumor growth and metastasis, the interactions between tumor and stromal cells via chemokine systems are essential. Several previous studies demonstrated that CX3CL1-CX3CR1 system was crucial in various disease models such as ischemia-reperfusion renal injury, bacterial peritonitis and inflammatory colitis. In this study, we explored the pathophysiological roles of CX3CL1-CX3CR1 system in ovarian cancer progression.
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| Free Research Field |
卵巣癌
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