2015 Fiscal Year Final Research Report
Role of R-spondin1 in corneal homeostasis
| Project/Area Number |
26861462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Nagata Maho 京都府立医科大学, 医学部附属病院, 後期特定専攻医 (40614102)
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| Research Collaborator |
Fullwood Nigel ランカスター大学, Biomedical and Life Science, Senior Lecturer
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 角膜上皮 / 細胞分化 / 創傷治癒 / 角膜混濁 / Wntシグナル / R-spondin1 / 分化異常 |
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| Outline of Final Research Achievements |
R-spondin1 (RSPO1) is a ligand of the Wnt signaling pathway that regulates crucial aspects of cell fate determination such as embryonic development, cell proliferation, and cell differentiation. Role of RSPO1 in corneal homeostasis was investigated. As a result, RSPO1 gene knockout mouse represented subepithelial corneal opacity, delay of corneal epithelial wound healing, and abnormality of corneal differentiation, that indicates the important role of RSPO1 in corneal homeostasis.
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| Free Research Field |
眼科学
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