Development of small sized vessel grafts from decellularized vessels

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861495
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Wang Wei 東京医科歯科大学, 生体材料工学研究所, 非常勤講師 (60451944)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 再生医療 / 小口径人口血管 / 生体材料

Outline of Final Research Achievements

We tried to develop a highly functional, long-term reliable, off-the-shelf product of small diameter vascular graft for the surgical treatment of ischemic deceases such like cardiac infarct. rat's arteries were harvested, decellularized and anti-coagulation treated for graft use. Through our study, we invented an automatic tissue decellularizing machine with inner and outer double circulation function; we optimized the procedure for vessel decellularization with a combination of SDS and ultrasonic bath; we confirmed the cell affinity of decellularized vessels. We tried lumen immobilization of several anti coagulation substances such like haperin, MPC polymers, long-term patency was not attained. Further experiments of lumen anti coagulation is needed.

Free Research Field

生体材料