2015 Fiscal Year Final Research Report
The examination of mechanisms underlying the xerostomia in type 2 diabetes mellitus by analysis of salivary gland hemodynamics.
| Project/Area Number |
26861557
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
SATO TOSHIYA 北海道医療大学, 歯学部, 助教 (30709241)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 糖尿病 / 唾液腺 / 血流動態 |
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| Outline of Final Research Achievements |
The present study examined the effects of type 2 diabetes mellitus on parasympathetic vasodilation in salivary glands using spontaneously-developed type 2 diabetic rats (OLETF rat) and nondiabetic control rats (LETO rat). The magnitude of the parasympathetic vasodilation in the parotid gland of diabetic rats was significantly lower than that of nondiabetic rats, but this was not the case in the submandibular and sublingual glands. Our results suggest that the disturbance of parasympathetic vasodilation in the parotid gland may play an important role in xerostomia in diabetes mellitus.
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| Free Research Field |
口腔生理学
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