2015 Fiscal Year Final Research Report
Modulation of osteoblast functions by Methylglyoxal
| Project/Area Number |
26861558
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | メチルグリオキサール / 骨芽細胞 / 石灰化 / AGEs / BMP / アルカリホスファターゼ |
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| Outline of Final Research Achievements |
Recently attention has been paid to the osteoporosis in diabetic patients. Bone fracture risks increase in type 2 diabetes patients without declining their bone mineral density. It is considered that denaturation of bone matrix by advanced glycation endproducts (AGEs) causes their bone fragility.
We examined the effect of methylglyoxal (MG), one of the AGEs, on calcification by osteoblastic MC3T3-E1 cells in vitro. MG caused increase in hardness and decrease in viscoelasticity of calcified nodules formed in the cultures of MC3T3-E1 cells. These results indicate a possibility that MG-induced change in physical properties of the calcified matrix causes the fragility of bones in patients with type 2 diabetes.
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| Free Research Field |
口腔生化学
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