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2017 Fiscal Year Final Research Report

Effects of micronutritional conditions on the expressions of taste receptors and related downstream elements in taste cells

Research Project

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Project/Area Number 26861563
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionAsahi University

Principal Investigator

Yasuo Toshiaki  朝日大学, 歯学部, 助教 (30608469)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords味覚 / ビタミンC / 欠乏 / 味細胞 / 茸状乳頭 / 鼓索神経 / 微量栄養素 / 末梢味覚器
Outline of Final Research Achievements

The purpose of this study was to examine the effects of vitamin C (VC) deficiency on peripheral taste organ.The results were as follows: The magnitudes of taste nerve responses to some organic acids and high concentrations (>100mM) of NaCl (high Na) in vitamin C deficient (VC-def) rats were smaller than those in non-deficient (ND) rats. Gene expression level of Gad1 and Car4, markers for acid and/or high Na responsive taste cells, decreased in VC-def rats. There was no difference in the number of taste buds on the anterior part of tongue between VC-def and ND rats. The behavioral experiments show that the rejection of citric acid during VC deficiency was decreased. The sodium-dependent VC transporter gene was detected in taste cells of these rats.
The behavioral and neural changes shown in this study may be due to down-expression of gene in high Na and sour responsive taste cells. This study also provide important new information about the presence of VC transport system in taste bud.

Free Research Field

口腔生理学

URL: 

Published: 2019-03-29  

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