Clarification of the pathology of BRONJ and establishment of a new treatment method

2017 Fiscal Year Final Research Report

• Project/Area Number: 26861577
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: YOSHIGA Daigo 九州歯科大学, 歯学部, 准教授 (10507784)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 免疫 / 骨粗鬆症 / BRONJ / テリパラチド

Outline of Final Research Achievements

Osteonecrosis of the jaw is a major complication in patients using bisphosphonate agents for bone lesions. Osteonecrosis was induced by intraperitoneal administration of zoledronic acid (ZOL). TPTD administration reduced necrotic bone area of the mandibles and femurs in the BRON rat model and induced new bone formation. In addition, TPTD injection increased the number of osteoclasts. In conclusion, the nitrogen-containing bisphosphonate (NBP) ZOL has negative effects on osteoclasts. TPTD was found to be effective in eliminating the negative effects of NBPs. TPTD had positive effects in preventing bone resorption and promoting osteogenesis. In addition, TPTD improved osteoclastogenesis, which in turn led to the improvement of BRON. These results demonstrate the effects of TPTD on the biomechanical properties of the bone in a BRON rat model. Taken together, we suggest that intermittent administration of TPTD could be an effective treatment for BRON of the jaw (BRONJ).

Free Research Field

口腔外科