Analysis of Wnt signal network in the differentiation of dental pulp stem cells and clinical dental pulp regeneration by Wnt-signal modified dental pulp stem cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861589
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Koizumi Yu 東京医科歯科大学, 歯学部, 非常勤講師 (70635549)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯髄幹細胞 / Wnt / シグナルネットワーク / 分化誘導 / 歯髄再生 / BMP2

Outline of Final Research Achievements

Wnt signaling is involved in virtually every aspect of embryonic development, and it is also involved in tooth development including dental pulp tissue. In this project, a crosstalk between Wnt signaling and BMP signaling in the dental pulp stem cells (DPCSs). BMP signaling induces odontoblastic differentiation of DPSCs, and it also stimulates Wnt expression and promotes Wnt signaling. Crosstalk between BMP and Wnt signaling may be essential for odontoblastic differentiation from DPSCs, and effective induction of crosstalk between BMP and Wnt signaling in DPSCs may be a key to promote odontoblastic differentiation in clinical pulp regeneration by DPCSs application.

Free Research Field

歯内療法学