Carbon nanomateral immobilized peptide for alveolar bone tissue engnieering

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861616
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Hokkaido University
• Principal Investigator: Hirata Eri 北海道大学, 歯学研究科, 助教 (10722019)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: カーボンナノ物質 / ナノテクノロジー / 骨再生

Outline of Final Research Achievements

1. The effect of carbon nanohorns on human monocyte and mesenchymal stem cells: CNHs thus accelerating the differentiation of mesenchymal stem cells into the osteoblasts via OSM. This study demonstrates one of the possible mechanisms for bone formation with CNHs and CNHs could be applied for bone regeneration. 2. CNH coated anodized titanium by electrodeposition: CNHs were fixed uniformly by electrophoretic deposition at a voltage 300V, processing time of 180 seconds. 7days after implantation showed new bone tissue contacted with CNHs directly. 3. Development of the CNHs functionalized bone morphogenic protein recepter binded peptide (DWIVA): Osteopontin of the cells cultured with CNH-bone DWIVA was significantly higher than that of CNH-control peptide and DWIVA itself. DWIVA binded CNHs could increase osteoblast differentiation more than DWIVA itself.

Free Research Field

補綴歯科理工学