2015 Fiscal Year Final Research Report
A new strategy for patients with xerostomia targeting ion channels by hyperthermia
| Project/Area Number |
26861648
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Taro Mukaibo 九州歯科大学, 歯学部, 助教 (50635117)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | TRPチャネル / 口腔乾燥症 / SOCE |
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| Outline of Final Research Achievements |
The aim of this study was to elucidate the mechanism of increased saliva secretion of salivary gland associated with temperature. Although TPR channel was studied as a SOCE (Store Operated Calcium Channel), that possibility was little according to the results of this study. Moreover, any difference was not detected in localization of channels and transporters relevant to saliva secretion between 25℃ and 37℃．Further study is necessary to show the mechanism of increased saliva secretion in accordance with the elevated temperature.
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| Free Research Field |
歯科補綴学・生理学
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