Elucidation of heterogeneity in tumor endothelial cell in oral cancer and application for new antiangiogenic drug

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861694
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Noritaka Ohga 北海道大学, 歯学研究科, 助教 (40548202)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腫瘍血管新生 / 腫瘍血管内皮マーカー / CXCR7

Outline of Final Research Achievements

In addition, we have reported that tumor endothelial cells (TECs) differ from normal endothelial cells (NECs) in many aspects, such as gene expression profiles. For example, CXCR7 is reportedly highly expressed in TECs of several tumors, such as renal carcinomas and colon cancers. However the expression of CXCR7 in oral squamous cell carcinoma (OSCC) has not been reported.In this study, we examined the relationship between CXCR7 expression in TECs and clinicopathological factors in OSCCs.CXCR7 expression in blood vessels was 42% and 19% in tumor tissue and in normal tissue, respectively, suggesting that CXCR7 expression is higher in TEC than in NEC in OSCC. The expression of CXCR7 in TEC were correlated with the T pathological stage (P=0.04).These results suggested that CXCR7 expression may be useful as a prognostic marker of OSCCs.

Free Research Field

腫瘍血管新生