Classification of extracapsular spread of the cervical lymph node metastasis in oral squamous cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861705
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Michikawa Chieko 東京医科歯科大学, 歯学部附属病院, 医員 (00622648)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 被膜外浸潤 / 分類 / リンパ節 / 口腔癌 / 扁平上皮癌

Outline of Final Research Achievements

Extracapsular spread (ECS) of cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) is independently recognized as the only marker of World Standard for planning post-operative chemoradiotherapy. I investigated the status of metastatic lymph nodes pathologically and morphologically in detail, and found that the patients with small nodes but ECS positive showed significantly worse outcome compared to those with ECS positive larger nodes. Moreover, I performed next generation sequencer using genomic DNA from primary OSCC and metastasis with ECS to seek genetic alterations associated with ECS.

Free Research Field

医歯薬学