2015 Fiscal Year Final Research Report
Involvement of helper T cells in the pathogenesis of HTLV-1-related Sjogren's syndrome
| Project/Area Number |
26861733
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | シェーグレン症候群 / HTLV-1 / Th / サイトカイン / ケモカイン |
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| Outline of Final Research Achievements |
Sjogren's syndrome (SS) is a chronic inflammatory disease mainly composed of the lymphocyte permeation of the exocrine gland including lacrimal gland and the salivary gland, but there are many any questions about the onset and condition of a pathological condition progress.I focus attention on human T cell leukemia virus type I (HTLV-1).A difference was seen by clinical manifestations and a test result in HTLV-1(+) SS and the HTLV-1(-) SS.The T cell which infected HTLV-1 accumulated it around duct in the pathology organization of labial glands.Furthermore, participation in condition of a patient formation was suggested because I strongly developed chemokines receptor CCR4 paid the attention to as a new therapeutic drug of leukemia.
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| Free Research Field |
口腔外科
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