Functional analysis of oral cancer stem cell-related microRNAs and development of novel therapies

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861736
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: Yoshida Ryoji 熊本大学, 生命科学研究部, 講師 (10632458)
• Co-Investigator(Renkei-kenkyūsha): ITO Takaaki 熊本大学, 大学院生命科学研究部, 教授 (70168392) ; NAKAYAMA Hideki 熊本大学, 大学院生命科学研究部, 教授 (70381001)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 口腔癌 / マイクロRNA / 治療抵抗性 / 転移

Outline of Final Research Achievements

The progression of treatment resistant cancer cells is a multistep and complicated process, frequently leading to a poor prognosis in cancer patients. Recently, growing evidence has indicated that deregulation of microRNAs (miRNAs) contributes to tumor progression in oral squamous cell carcinoma (OSCC),such as metastasis,chmoresistance and radioresistance. The purpose of this study was to investigate the functional significance of tumor-suppressive miRNA in cancer cells and to identify novel miRNA-mediated cancer pathways and responsible genes in treatment resistant OSCC, especially metastasis. In the present study, metastasis-related miRNA (tentative name; miR-X） has a tumor-suppressing role in metastasis in OSCC via regulating metastasis related molecules, suggesting miR-X as a potential new diagnostic and therapeutic target for the treatment of OSCC.

Free Research Field

口腔扁平上皮癌