2015 Fiscal Year Final Research Report
A study of novel BP180 C-terminal domain ELISA on mucous membrane pemphigoid
| Project/Area Number |
26861762
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 口腔外科学 |
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| Outline of Final Research Achievements |
Diagnosis of anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is frustrated by the difficulty of detecting BP180 reactivity. 332 patients were tentatively diagnosed with BP180-MMP.
Clinically, a predominance of female patients was diagnosed. Oral mucosal and cutaneous lesions were found in 85.5% and 41.0% of patients, respectively, and frequent treatments were systemic steroids.
Various immunological methods, including a newly developed BP180 C-terminal domain enzyme-linked immunoassay (BP180CT ELISA), revealed frequent reactivity with BP180 C-terminal on MMP patients. This large study of patients with suspected BP180-MMP indicates the difficulty of diagnosis of BP180-MMP and the diagnostic usefulness of BP180 CT ELISA.
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| Free Research Field |
口腔外科学
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