The elucidation of mechanotransduction of integrins and establishment of the PCR prevention with integrins inhibitor

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861788
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Hirose Naoto 広島大学, 医歯薬保健学研究院, 助教 (50611935)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: インテグリン / ＰＣＲ / 顎関節症

Outline of Final Research Achievements

We ocnducted experiments for searching for the new treatment for PCR. It was already elucidated that mechanical stress was received at integrins on the surface of chondrocytes'cell membrane. We elucidated in this research that Cilengitide, which is the inhibitor of integrinαVβ5, inhibits receptive mechanism and finally suppresses the expression of inflammatory cytokines via integrin-FAK signaling. Additionally, We establish the rat model which condyle becomes overloaded in vivo experiments. however, we weren't able to accomplish this task because of some difficulties of how to inject cilengitide and reach it there.

Free Research Field

矯正歯科学