The role of histone deacetylase during early mandibular development in rat.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861794
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: Terao Fumie 九州大学, 歯学研究科(研究院), 助教 (10510018)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 歯学 / 発生・分化 / ヒストン脱アセチル化

Outline of Final Research Achievements

The aim of this study is to elucidate the mechanism of pattern formation regulated by histone deacetylase (Hdac) during rat embryonic mandibular development. Knockdown of Hdac1 in rat mandibular organ culture up-regulated the gene expression of endothelin receptor type A (Ednra) and Hoxa2. It is well known that Ednra is expressed by the neural crest-derived ectomesenchymal cells of mandibular arch, and plays an important role during mandibular pattern formation. Hoxa2 is a marker for the second branchial arch. Up-regulation of Hoxa2 gene expression in the first arch indicates that Hdac1 knockdown leads to a transformation of second arch. These data suggests that Hdac1 plays an important role during rat embryonic mandibular development by regulating key gene expression.

Free Research Field

医歯薬学