Effect of functional hypofunction following botulinum neurotoxin injections on craniofacial growth and development of masticatory function.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861795
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: UTSUMI Dai 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80622604)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯学 / マウス / ボツリヌストキシン

Outline of Final Research Achievements

In the present study, we use the mice model for evaluating the effect of muscle hypofunction following botulinum neurotoxin injections on the craniofacial morphology and masticatory function.Three-dimensional jaw movements and EMG of the masseter and temporalis muscles were recorded while mice were chewing.
In the hypofunction group, muscle activities and jaw movement trajectoryies were changed. We found that the masseter plays an important role in stabilizing the grinding path, and the temporalis plays a major role in retracting the mandible more posteriorly in the early phase of closing, extending the grinding path. Furthermore, these results suggest that a part of functional disorders affect other coordination of mastication.

Free Research Field

歯科矯正学