2015 Fiscal Year Final Research Report
Elucidating the mechanism of drug-indcued gingival overgrowth using disease model
| Project/Area Number |
26861815
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 薬物性歯肉増殖症 / シクロスポリン / マウスモデル |
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| Outline of Final Research Achievements |
Conventional therapy for drug-induced gingival overgrowth(DIGO) is demanded. Animal disease model is essential for developing novel therapy. In the current study we developed mouse DIGO model by which silk sutures were pre-ligated before the application of CsA. Anitibiotics inhibited the initiation of CsA induced gingival overgrowth. Furtheremore tacrolimus which have calcineurin inhibition activity same as CsA also induced gingival overgrowth. Cessation of CsA administration improved gingival overgrowth. In conclusion, Bacteriao infection and calcineurin activity is involved in initiation of CsA indced gingival overgrowth. In the future, it is promising that revealing the mechanismas of DIGO by using our mouse DIGO model.
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| Free Research Field |
歯周治療
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