Prevention of bacteremia by custom-made tooth brush which was outputted by CAD/CAM.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Tsurumi University
• Principal Investigator: KAKUTA Erika 鶴見大学, 歯学部, 助教 (30585469)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 歯原性菌血症 / 動脈硬化 / 3Dプリンタ(CAD/CAM)

Outline of Final Research Achievements

Arteriosclerosis and high-blood pressure were considered as risk factors of odontogenic bacteremia. The aim of this study was to estimate the effect of custom-made tooth brush for prevention of odontogenic bacteremia.
To search for diagnostic marker of odontogenic bacteremia that 26 saliva samples of DNA extracted were examined by quantitative PCR and T-RFLP. The custom-made tooth brush was outputted by CAD/CAM. The 19 subjects were examined for salivary bacteria and arteriosclerosis test were measured at first visit and after Dental Drug Delivery System (3DS therapy) to estimate the effect of custom-made tooth brush for prevention of odontogenic bacteremia. After 3DS therapy of Streptococcus mutans counts and blood pressure was significant lower than first visit of that.
In conclusion, it suggested that the concentration of volatile sulfur compound was able to predict Veillonella and Fusobacterium ratios. And also 3DS therapy may be effective method for blood pressure control.

Free Research Field

口腔微生物学