2017 Fiscal Year Final Research Report
Protein expression analysis of leucine-rich alpha-2-glycoprotein in serum as a new diagnostic marker of pancreatic cancer focusing on the posttranslational modification
| Project/Area Number |
26870002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
Tumor diagnostics
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 膵癌 / バイオマーカー |
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| Outline of Final Research Achievements |
The prognosis of pancreatic cancer (PC) is extremely poor and it is difficult to diagnose PC in early stage. We analyzed leucine-rich alpha-2-glycoprotein (LRG) in serum as a new diagnostic marker of PC. We used the serum of PC patients (n=68) and healthy volunteer (n=10) and analyzed the serum concentration of LRG by ELISA. We found that LRG levels of PC patients in all stages were significantly up-regulated compared with those of healthy volunteers. Moreover, LRG concentrations were highly expressed in 22 of 25 PC patients whose serum levels of CA19-9 were low. LRG is a candidate of new diagnostic marker of PC. We plan to isolate LRG from serum and analyze differentially expressed glycans of LRG in future research.
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| Free Research Field |
肝胆膵外科
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