2015 Fiscal Year Final Research Report
Analysis of molecular mechanisms for the filamin-induced defensive force of normal epithelial cells against cancer
| Project/Area Number |
26870004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Tumor biology
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| Research Institution | Tokyo Medical and Dental University (2015)
Hokkaido University (2014) |
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Principal Investigator |
Kajita Mihoko 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 (00607442)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | filamin / EDAC / SILAC / Caveolin / EPLIN / S1P |
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| Outline of Final Research Achievements |
Normal epithelial cells recognize and extrude neighboring transformed cells from an epithelial monolayer. We named this process as EDAC (Epithelial Defense Against Cancer). In this project, I focused on filamin, which plays a central role for EDAC, to understand molecular mechanisms for EDAC. Several molecules were successfully identified as increased binding to filamin under the mix culture of normal and transformed cells. Furthermore, the interaction between newly identified EDAC-inducing molecules and filamin was also elucidated.
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| Free Research Field |
分子腫瘍学、免疫学
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