2015 Fiscal Year Final Research Report
The establishment of antigen specific therapy for Sjogren syndrome
| Project/Area Number |
26870078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
Collagenous pathology/Allergology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 抗原特異的治療法 / シェーグレン症候群 / アナジー |
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| Outline of Final Research Achievements |
Rag1-/- mice transferred with splenocytes of M3 muscarinic acetylcoline receptor (M3R)-/- mice immunized with M3R peptides mixture (N-terminal regions; N1, N2, N3, and three extracellular loops; 1st, 2nd, 3rd) developed sialadenitis like Sjogren’s syndrome (SS) (M3R induced sialadenitis; MIS). we confirmed that in MIS, M3R reactive CD4+ T cells were indispensable and the T cell epitopes were both N1 and 1st regions. Besides, altered peptide ligands (APLs) , substituted in amino acid residues at TCR contact sites, of N1 peptide can regulate the T cell activation by inducing anergy, leading to the suppression of sialadenitis in vivo. This research was reported by the journal of 'Arthritis and Rheumatology'.
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| Free Research Field |
自己免疫
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