Regulation of the differentiation of pathogenic T cells in autoimmune arthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870081
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology; Collagenous pathology/Allergology
• Research Institution: University of Tsukuba
• Principal Investigator: Kondo Yuya 筑波大学, 医学医療系, 講師 (40612487)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 自己免疫性関節炎 / T細胞 / 分化 / 転写因子 / サイトカイン

Outline of Final Research Achievements

We have examined the role of transcription factors regulating the differentiation of CD4+ T cells in the development of autoimmune arthritis.In the analyses of animal model of autoimmune arthritis, we showed the possibility that Th-17 specific master transcription factor RORgt-expressing Foxp3+ regulatory T cells might regulate the development of autoimmune arthritis via the suppression of arthritogenic Th-17 cells in RORgt trangenic mice (Kondo Y et al. Arthritis Res Ther 2015).
Our results suggested possibility that control of the differentiation of CD4+ T cells might be a novel therapeutic strategy in autoimmune arthritis.

Free Research Field

膠原病・リウマチ学