Pathological and genomic study of ovarian mucinous adenocarcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology; Human pathology
• Research Institution: Akita University
• Principal Investigator: MAEDA DAICHI 秋田大学, 医学(系)研究科(研究院), 准教授 (30585500)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 卵巣粘液性腫瘍

Outline of Final Research Achievements

We investigated ovarian mucinous tumor focusing on the difference between gastrointestinal-type and endocervical-type mucinous tumors. With regard to endocervical-type mucinous tumors, we investigated ARID1A alterations which is known to play an oncogenic role in endometriosis-associated ovarian cancer. As a result, loss of ARID1A expression, which suggests presence of mutation, was observed in a subset of endocervical-type mucinous borderline tumor. The loss of ARID1A expression was also observed in adjacent endometriotic epithelium. This finding suggest that ARID1A is involved in tumorigenesis of endocervical-type mucinous tumors. Further, ARID1A alteration occur in an early phase of its tumorigenesis.

Free Research Field

人体病理学